Maglia Lab @ KU Leuven

The main focus of our group is on the chemistry and biophysics of membrane proteins systems, especially nanopores. We are engineering, modifying and redesigning these protein systems for applications in NanoBioTechnology and Single-Molecule Biophysics.

We are using biological nanopores in:

• Single-enzyme kinetics and folding studies
• Applications in single-molecule DNA sequencing
• Nanofluidic approaches for smart drug delivery
• Integrated devices for single-molecule characterization

Selected publications

Maglia, G., Heron, A. J., Hwang, W. L., Holden, M. A., Mikhailova, E., Li, Q., Cheley, S., and Bayley, H., Droplet networks with incorporated protein diodes show collective properties. Nature Nanotechnology 4 (7), 437-440 (2009).

  -Featured in News and Views. Nature Nanotechnology. A fluid approach to simple circuits 2009, 4, 403-404

  -Featured in New Scientist. 17/06/09 Synthetic cells get together to make electronics.

Stoddart, D., Heron, A.J., Mikhailova, E., Maglia, G., and Bayley, H., Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc Natl Acad Sci U S A 106 (19), 7702-7707 (2009).

  -Featured in From the Cover, Proc Natl Acad Sci U S A. Nanopore DNA sequencing. 2009, 106, 7681

Restrepo, M.R., Mikhailova, E., Bayley, H., and Maglia, G. Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes. Nano Letters. Feb 9;11(2):746-50 (2011).